diff --git a/drivers/i2c/busses/i2c-i801.c b/drivers/i2c/busses/i2c-i801.c
index 4f333889489c..fea644921a76 100644
--- a/drivers/i2c/busses/i2c-i801.c
+++ b/drivers/i2c/busses/i2c-i801.c
@@ -1318,6 +1318,12 @@ static void i801_probe_optional_slaves(struct i801_priv *priv)
 
 	if (is_dell_system_with_lis3lv02d())
 		register_dell_lis3lv02d_i2c_device(priv);
+
+	/* Instantiate SPD EEPROMs unless the SMBus is multiplexed */
+#if IS_ENABLED(CONFIG_I2C_MUX_GPIO)
+	if (!priv->mux_drvdata)
+#endif
+		i2c_register_spd(&priv->adapter);
 }
 #else
 static void __init input_apanel_init(void) {}