diff --git a/drivers/nvme/host/core.c b/drivers/nvme/host/core.c
index 2cc6192ef275..eab812dd2429 100644
--- a/drivers/nvme/host/core.c
+++ b/drivers/nvme/host/core.c
@@ -1705,7 +1705,8 @@ static void nvme_set_queue_limits(struct nvme_ctrl *ctrl,
 		blk_queue_max_hw_sectors(q, ctrl->max_hw_sectors);
 		blk_queue_max_segments(q, min_t(u32, max_segments, USHRT_MAX));
 	}
-	if (ctrl->quirks & NVME_QUIRK_STRIPE_SIZE)
+	if ((ctrl->quirks & NVME_QUIRK_STRIPE_SIZE) &&
+	    is_power_of_2(ctrl->max_hw_sectors))
 		blk_queue_chunk_sectors(q, ctrl->max_hw_sectors);
 	blk_queue_virt_boundary(q, ctrl->page_size - 1);
 	if (ctrl->vwc & NVME_CTRL_VWC_PRESENT)