diff --git a/drivers/gpio/gpio-pca953x.c b/drivers/gpio/gpio-pca953x.c
index bf21803a0036..9ce54bf2030d 100644
--- a/drivers/gpio/gpio-pca953x.c
+++ b/drivers/gpio/gpio-pca953x.c
@@ -768,6 +768,8 @@ static void pca953x_irq_bus_sync_unlock(struct irq_data *d)
 	int level;
 
 	if (chip->driver_data & PCA_PCAL) {
+		guard(mutex)(&chip->i2c_lock);
+
 		/* Enable latch on interrupt-enabled inputs */
 		pca953x_write_regs(chip, PCAL953X_IN_LATCH, chip->irq_mask);