diff --git a/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.s390x-latest.args b/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.s390x-latest.args
new file mode 100644
index 0000000000..9704d7d5e9
--- /dev/null
+++ b/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.s390x-latest.args
@@ -0,0 +1,41 @@
+LC_ALL=C \
+PATH=/bin \
+HOME=/var/lib/libvirt/qemu/domain--1-QEMUGuest1 \
+USER=test \
+LOGNAME=test \
+XDG_DATA_HOME=/var/lib/libvirt/qemu/domain--1-QEMUGuest1/.local/share \
+XDG_CACHE_HOME=/var/lib/libvirt/qemu/domain--1-QEMUGuest1/.cache \
+XDG_CONFIG_HOME=/var/lib/libvirt/qemu/domain--1-QEMUGuest1/.config \
+/usr/bin/qemu-system-s390x \
+-name guest=QEMUGuest1,debug-threads=on \
+-S \
+-object '{"qom-type":"secret","id":"masterKey0","format":"raw","file":"/var/lib/libvirt/qemu/domain--1-QEMUGuest1/master-key.aes"}' \
+-machine s390-ccw-virtio,usb=off,dump-guest-core=off \
+-accel kvm \
+-cpu gen16a-base \
+-m size=2095104k,maxmem=1099511627776k \
+-overcommit mem-lock=off \
+-smp 2,sockets=2,cores=1,threads=1 \
+-object '{"qom-type":"memory-backend-ram","id":"ram-node0","size":2145386496}' \
+-numa node,nodeid=0,cpus=0-1,memdev=ram-node0 \
+-uuid c7a5fdbd-edaf-9455-926a-d65c16db1809 \
+-display none \
+-no-user-config \
+-nodefaults \
+-chardev socket,id=charmonitor,fd=1729,server=on,wait=off \
+-mon chardev=charmonitor,id=monitor,mode=control \
+-rtc base=utc \
+-no-shutdown \
+-boot strict=on \
+-device '{"driver":"zpci","uid":1,"fid":0,"target":"pci.1","id":"zpci1"}' \
+-device '{"driver":"pci-bridge","chassis_nr":1,"id":"pci.1","bus":"pci.0","addr":"0x1"}' \
+-object '{"qom-type":"memory-backend-ram","id":"memvirtiomem0","reserve":false,"size":1073741824}' \
+-device '{"driver":"virtio-mem-pci","node":0,"block-size":2097152,"requested-size":536870912,"memdev":"memvirtiomem0","id":"virtiomem0","bus":"pci.0","addr":"0x2"}' \
+-object '{"qom-type":"memory-backend-file","id":"memvirtiomem1","mem-path":"/dev/hugepages2M/libvirt/qemu/-1-QEMUGuest1","reserve":false,"size":2147483648,"host-nodes":[1,2,3],"policy":"bind"}' \
+-device '{"driver":"virtio-mem-pci","node":0,"block-size":2097152,"requested-size":1073741824,"memdev":"memvirtiomem1","prealloc":true,"memaddr":5637144576,"dynamic-memslots":true,"id":"virtiomem1","bus":"pci.1","addr":"0x1"}' \
+-blockdev '{"driver":"host_device","filename":"/dev/HostVG/QEMUGuest1","node-name":"libvirt-1-storage","read-only":false}' \
+-device '{"driver":"virtio-blk-ccw","devno":"fe.0.0000","drive":"libvirt-1-storage","id":"virtio-disk0","bootindex":1}' \
+-audiodev '{"id":"audio1","driver":"none"}' \
+-device '{"driver":"virtio-balloon-ccw","id":"balloon0","devno":"fe.0.0001"}' \
+-sandbox on,obsolete=deny,elevateprivileges=deny,spawn=deny,resourcecontrol=deny \
+-msg timestamp=on
diff --git a/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.s390x-latest.xml b/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.s390x-latest.xml
new file mode 100644
index 0000000000..336c6e5aac
--- /dev/null
+++ b/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.s390x-latest.xml
@@ -0,0 +1,71 @@
+<domain type='kvm'>
+  <name>QEMUGuest1</name>
+  <uuid>c7a5fdbd-edaf-9455-926a-d65c16db1809</uuid>
+  <maxMemory unit='KiB'>1099511627776</maxMemory>
+  <memory unit='KiB'>8388608</memory>
+  <currentMemory unit='KiB'>8388608</currentMemory>
+  <vcpu placement='static' cpuset='0-1'>2</vcpu>
+  <os>
+    <type arch='s390x' machine='s390-ccw-virtio'>hvm</type>
+    <boot dev='hd'/>
+  </os>
+  <cpu mode='custom' match='exact' check='none'>
+    <model fallback='forbid'>gen16a-base</model>
+    <numa>
+      <cell id='0' cpus='0-1' memory='2095104' unit='KiB'/>
+    </numa>
+  </cpu>
+  <clock offset='utc'/>
+  <on_poweroff>destroy</on_poweroff>
+  <on_reboot>restart</on_reboot>
+  <on_crash>destroy</on_crash>
+  <devices>
+    <emulator>/usr/bin/qemu-system-s390x</emulator>
+    <disk type='block' device='disk'>
+      <driver name='qemu' type='raw'/>
+      <source dev='/dev/HostVG/QEMUGuest1'/>
+      <target dev='hda' bus='virtio'/>
+      <address type='ccw' cssid='0xfe' ssid='0x0' devno='0x0000'/>
+    </disk>
+    <controller type='pci' index='0' model='pci-root'/>
+    <controller type='pci' index='1' model='pci-bridge'>
+      <model name='pci-bridge'/>
+      <target chassisNr='1'/>
+      <address type='pci' domain='0x0000' bus='0x00' slot='0x01' function='0x0'>
+        <zpci uid='0x0001' fid='0x00000000'/>
+      </address>
+    </controller>
+    <audio id='1' type='none'/>
+    <memballoon model='virtio'>
+      <address type='ccw' cssid='0xfe' ssid='0x0' devno='0x0001'/>
+    </memballoon>
+    <panic model='s390'/>
+    <memory model='virtio-mem'>
+      <target>
+        <size unit='KiB'>1048576</size>
+        <node>0</node>
+        <block unit='KiB'>2048</block>
+        <requested unit='KiB'>524288</requested>
+      </target>
+      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x0'>
+        <zpci uid='0x0002' fid='0x00000001'/>
+      </address>
+    </memory>
+    <memory model='virtio-mem'>
+      <source>
+        <nodemask>1-3</nodemask>
+        <pagesize unit='KiB'>2048</pagesize>
+      </source>
+      <target dynamicMemslots='yes'>
+        <size unit='KiB'>2097152</size>
+        <node>0</node>
+        <block unit='KiB'>2048</block>
+        <requested unit='KiB'>1048576</requested>
+        <address base='0x150000000'/>
+      </target>
+      <address type='pci' domain='0x0000' bus='0x01' slot='0x01' function='0x0'>
+        <zpci uid='0x0003' fid='0x00000002'/>
+      </address>
+    </memory>
+  </devices>
+</domain>
diff --git a/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.xml b/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.xml
new file mode 100644
index 0000000000..747877042a
--- /dev/null
+++ b/tests/qemuxmlconfdata/memory-hotplug-virtio-mem-pci-s390x.xml
@@ -0,0 +1,59 @@
+<domain type='kvm'>
+  <name>QEMUGuest1</name>
+  <uuid>c7a5fdbd-edaf-9455-926a-d65c16db1809</uuid>
+  <maxMemory unit='KiB'>1099511627776</maxMemory>
+  <memory unit='KiB'>8388608</memory>
+  <currentMemory unit='KiB'>8388608</currentMemory>
+  <vcpu placement='static' cpuset='0-1'>2</vcpu>
+  <os>
+    <type arch='s390x' machine='s390-ccw-virtio'>hvm</type>
+    <boot dev='hd'/>
+  </os>
+  <cpu mode='custom' match='exact' check='none'>
+    <model fallback='forbid'>gen16a-base</model>
+    <numa>
+      <cell id='0' cpus='0-1' memory='2095104' unit='KiB'/>
+    </numa>
+  </cpu>
+  <clock offset='utc'/>
+  <on_poweroff>destroy</on_poweroff>
+  <on_reboot>restart</on_reboot>
+  <on_crash>destroy</on_crash>
+  <devices>
+    <emulator>/usr/bin/qemu-system-s390x</emulator>
+    <disk type='block' device='disk'>
+      <driver name='qemu' type='raw'/>
+      <source dev='/dev/HostVG/QEMUGuest1'/>
+      <target dev='hda' bus='virtio'/>
+      <address type='ccw' cssid='0xfe' ssid='0x0' devno='0x0000'/>
+    </disk>
+    <controller type='pci' index='0' model='pci-root'/>
+    <audio id='1' type='none'/>
+    <memballoon model='virtio'>
+      <address type='ccw' cssid='0xfe' ssid='0x0' devno='0x0001'/>
+    </memballoon>
+    <memory model='virtio-mem'>
+      <target>
+        <size unit='KiB'>1048576</size>
+        <node>0</node>
+        <block unit='KiB'>2048</block>
+        <requested unit='KiB'>524288</requested>
+      </target>
+      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x0'/>
+    </memory>
+    <memory model='virtio-mem'>
+      <source>
+        <nodemask>1-3</nodemask>
+        <pagesize unit='KiB'>2048</pagesize>
+      </source>
+      <target dynamicMemslots='yes'>
+        <size unit='KiB'>2097152</size>
+        <node>0</node>
+        <block unit='KiB'>2048</block>
+        <requested unit='KiB'>1048576</requested>
+        <address base='0x150000000'/>
+      </target>
+      <address type='pci' domain='0x0000' bus='0x01' slot='0x01' function='0x0'/>
+    </memory>
+  </devices>
+</domain>
diff --git a/tests/qemuxmlconftest.c b/tests/qemuxmlconftest.c
index 49f13d1c6b..768c0ce34e 100644
--- a/tests/qemuxmlconftest.c
+++ b/tests/qemuxmlconftest.c
@@ -2715,6 +2715,7 @@ mymain(void)
      * virDomainMemoryDefCheckConflict() works for NVDIMMs which are special
      * than other memory devices because of how they handle <labelsize/> */
     DO_TEST_CAPS_LATEST("memory-hotplug-nvdimm-overlap");
+    DO_TEST_CAPS_ARCH_LATEST("memory-hotplug-virtio-mem-pci-s390x", "s390x");
 
     DO_TEST_CAPS_ARCH_LATEST("machine-aeskeywrap-on-caps", "s390x");
     DO_TEST_CAPS_ARCH_LATEST("machine-aeskeywrap-on-cap", "s390x");