diff --git a/src/conf/domain_conf.c b/src/conf/domain_conf.c
index fa8118137c..ee126cc8a2 100644
--- a/src/conf/domain_conf.c
+++ b/src/conf/domain_conf.c
@@ -14375,6 +14375,19 @@ virDomainHostdevMatchSubsysSCSIiSCSI(virDomainHostdevDefPtr first,
     return 0;
 }
 
+static int
+virDomainHostdevMatchSubsysMediatedDev(virDomainHostdevDefPtr a,
+                                       virDomainHostdevDefPtr b)
+{
+    virDomainHostdevSubsysMediatedDevPtr src_a = &a->source.subsys.u.mdev;
+    virDomainHostdevSubsysMediatedDevPtr src_b = &b->source.subsys.u.mdev;
+
+    if (STREQ(src_a->uuidstr, src_b->uuidstr))
+        return 1;
+
+    return 0;
+}
+
 static int
 virDomainHostdevMatchSubsys(virDomainHostdevDefPtr a,
                             virDomainHostdevDefPtr b)
@@ -14406,6 +14419,7 @@ virDomainHostdevMatchSubsys(virDomainHostdevDefPtr a,
         else
             return 0;
     case VIR_DOMAIN_HOSTDEV_SUBSYS_TYPE_MDEV:
+        return virDomainHostdevMatchSubsysMediatedDev(a, b);
     case VIR_DOMAIN_HOSTDEV_SUBSYS_TYPE_LAST:
         return 0;
     }