diff --git a/src/conf/domain_conf.c b/src/conf/domain_conf.c
index ea6a097161..22c6ba3b0d 100644
--- a/src/conf/domain_conf.c
+++ b/src/conf/domain_conf.c
@@ -5396,6 +5396,24 @@ virDomainVsockDefPostParse(virDomainVsockDefPtr vsock)
 }
 
 
+static int
+virDomainMemoryDefPostParse(virDomainMemoryDefPtr mem,
+                            const virDomainDef *def)
+{
+    /* Although only the QEMU driver implements PPC64 support, this
+     * code is related to the platform specification (PAPR), i.e. it
+     * is hypervisor agnostic, and any future PPC64 hypervisor driver
+     * will have the same restriction.
+     */
+    if (ARCH_IS_PPC64(def->os.arch) &&
+        mem->model == VIR_DOMAIN_MEMORY_MODEL_NVDIMM &&
+        virDomainNVDimmAlignSizePseries(mem) < 0)
+        return -1;
+
+    return 0;
+}
+
+
 static int
 virDomainDeviceDefPostParseCommon(virDomainDeviceDefPtr dev,
                                   const virDomainDef *def,
@@ -5437,6 +5455,10 @@ virDomainDeviceDefPostParseCommon(virDomainDeviceDefPtr dev,
         ret = virDomainVsockDefPostParse(dev->data.vsock);
         break;
 
+    case VIR_DOMAIN_DEVICE_MEMORY:
+        ret = virDomainMemoryDefPostParse(dev->data.memory, def);
+        break;
+
     case VIR_DOMAIN_DEVICE_LEASE:
     case VIR_DOMAIN_DEVICE_FS:
     case VIR_DOMAIN_DEVICE_INPUT:
@@ -5451,7 +5473,6 @@ virDomainDeviceDefPostParseCommon(virDomainDeviceDefPtr dev,
     case VIR_DOMAIN_DEVICE_SHMEM:
     case VIR_DOMAIN_DEVICE_TPM:
     case VIR_DOMAIN_DEVICE_PANIC:
-    case VIR_DOMAIN_DEVICE_MEMORY:
     case VIR_DOMAIN_DEVICE_IOMMU:
     case VIR_DOMAIN_DEVICE_AUDIO:
         ret = 0;
diff --git a/tests/qemuxml2xmloutdata/memory-hotplug-nvdimm-ppc64.xml b/tests/qemuxml2xmloutdata/memory-hotplug-nvdimm-ppc64.xml
index ae5a17d3c8..ecb1b83b4a 100644
--- a/tests/qemuxml2xmloutdata/memory-hotplug-nvdimm-ppc64.xml
+++ b/tests/qemuxml2xmloutdata/memory-hotplug-nvdimm-ppc64.xml
@@ -38,7 +38,7 @@
         <path>/tmp/nvdimm</path>
       </source>
       <target>
-        <size unit='KiB'>550000</size>
+        <size unit='KiB'>524416</size>
         <node>0</node>
         <label>
           <size unit='KiB'>128</size>