diff --git a/ci/gitlab/builds.yml b/ci/gitlab/builds.yml
index f070db637c..545478d351 100644
--- a/ci/gitlab/builds.yml
+++ b/ci/gitlab/builds.yml
@@ -865,7 +865,6 @@ aarch64-macos-12:
   needs: []
   allow_failure: false
   variables:
-    CFLAGS: -O0
     CIRRUS_VM_IMAGE_NAME: ghcr.io/cirruslabs/macos-monterey-base:latest
     CIRRUS_VM_IMAGE_SELECTOR: image
     CIRRUS_VM_INSTANCE_TYPE: macos_instance
diff --git a/ci/manifest.yml b/ci/manifest.yml
index 2f631376b2..b68c7361ab 100644
--- a/ci/manifest.yml
+++ b/ci/manifest.yml
@@ -179,8 +179,6 @@ targets:
         variables:
           PATH_EXTRA: /usr/local/opt/ccache/libexec:/usr/local/opt/gettext/bin:/usr/local/opt/libpcap/bin:/usr/local/opt/libxslt/bin:/usr/local/opt/rpcgen/bin
           PKG_CONFIG_PATH: /usr/local/opt/curl/lib/pkgconfig:/usr/local/opt/libpcap/lib/pkgconfig:/usr/local/opt/libxml2/lib/pkgconfig:/usr/local/opt/ncurses/lib/pkgconfig:/usr/local/opt/readline/lib/pkgconfig
-          # Remove once macos has clang with -fsemantic-interposition
-          CFLAGS: -O0
 
   ubuntu-2004:
     jobs: